中文摘要：

-catenin 基因为在脊椎动物的正常背面的轴的结构的形成是必要的。最近的研究提供了 -catenin 在在 zebrafish 和 Xenopus laevis 限制导致组织者的 neurectoderm 形成的数量有某个角色的证据。进一步理解 -catenin 怎么镇压 neurectoderm 形成的正式就职并且神经祖先命运的抑制是否为正常组织者形成是必要的， -catenin 是否涉及镇压，被调查早神经的规章的基因视觉系统 homeobox-1 (vsx1 ) 表示在 embryogenesis 期间。由 morpholino oligonucleotides (瞬间) 的内长的 -catenin 的功能的抑制导致了广泛、无所不在的 vsx1 表示，这被观察， -catenin 能镇压 vsx1 倡导者驱动的 GFP 表示和 transcriptional 因素基因 boz， -catenin, 的直接目标基因能直接镇压由到 vsx1 的绑定的 vsx1 抄写近似倡导者。这些观察显示 -catenin 能镇压 vsx1 宫外的表示房间独立地当它在 chordamesoderm 的先驱的房间激活 chordamesodermal 基因表示时，由 -catenin 在先驱的 chordamesoderm 建议 chordamesodermal 基因的两激活和神经规章的基因 vsx1 的压抑为正常脊索是必要的形成。

英文摘要：

β-catenin gene is essential for the formation of normal dorsal axial structure in vertebrates. Recent studies have provided evidence that β-catenin has a certain role in restricting the amount of organizer-induced neurectoderm formation in zebrafish and Xenopus laevis. To further understand how β-catenin represses the induction of neurectoderm formation and whether the inhibition of neural progenitor fates is essential for the normal organizer formation, it was investigated whether β-catenin was involved in repressing the early neural regulatory gene Visual system homeobox-1 （vsxl） expression during embryogenesis. It was observed that functional inhibition of endogenous β-catenin by morpholino oligonucleotides （MO） resulted in extensive and ubiquitous vsxl expression, 1%catenin could repress vsxl promoter-driven GFP expression and transcriptional factor gene boz, the direct target gene of β-catenin, could directly repress vsxl transcription by binding to vsxl proximal promoter. These observations indicate that β-catenin can repress vsxl ectopic expression cell-autonomously while it activates chordamesodermal genes expression in the precursory cells of chordamesoderm, suggesting both activation of chordamesodermal genes and repression of neural regulatory genes vsxl in precursory chordamesoderm by β-catenin are essential for normal notochord formation.