10号染色体上缺失的磷酸酶与张力蛋白同源物基因(PTEN)在神经系统中具有重要作用,参与调控神经细胞的增殖、迁移、分化、凋亡和突触建立。对FFEN及其功能的深入研究将有助于更清楚的了解神经系统的发育,推动靶向PTEN的神经系统疾病治疗。
Phosphatase and tensin homology deleted on chromosome 10 (PTEN) plays an important role in the proliferation,migration, differentiation, apoptosis and synapse establishment of nervous system. Elucidation of PTEN function is helpful to understand the mechanisms of neural development,and thus may find new therapies for diseases in central nervous system using PTEN as a target.