中文摘要：

斑马鱼作为一种新型的模式动物,以其独特的优势,已经成为现代遗传学、发育生物学等研究的重要模式生物. 与人类及其他高等脊椎动物相似,斑马鱼同样具有不同的组织屏障系统. 近年来,此领域的研究者利用斑马鱼对血脑屏障等组织屏障的研究取得了重要的进展. 这对揭示诸多生理屏障相关的人类疾病的发病机制,以及探讨通过调控组织屏障通透性来达到药物有效投递的可行性等研究具有重要的启示作用. 本文将介绍近年来斑马鱼作为模式动物在血脑屏障、血-视网膜屏障、皮肤表皮屏障、肠黏膜上皮屏障等组织屏障发育和功能研究中的最新进展.

英文摘要：

Zebrafish has been widely used as an important model system in research fields of genetic and develop -mental biology over the past 20 years.Similar to the mammalians and other vertebrate animals , zebrafish also has various tissue barriers.In recent years, more and more important progress of tissue barrier studies have been achieved using ze -brafish as in vivo model, such as blood-brain barrier.These findings contribute to the understanding of the mechanisms of diseases caused by the disorders of physiological barriers .It also helps with the modulation of the permeability of tissue bar-riers for drug delivery .This review summaries recent progress of zebrafish applications in the study of tissue barriers , such as blood-brain barrier, blood-retina barrier, epidermal barrier, etc.