中文摘要：

一磷酸鞘氨醇（S1P）是一种具有生物活性的磷脂信使,在体内主要由血小板和肥大细胞分泌,其对细胞的生长、增殖以及迁移等具有重要作用.S1P对心脏具有保护作用,尤其是在心脏缺血再灌注时,其能够降低缺血再灌注的损伤程度,减少心肌梗死面积、降低心律失常的发生.S1P还具有调节血管通透性以及抗动脉粥样硬化的作用.S1P的生物学效应的发生涉及多种信号通路,包括Akt、ERK、Rho等.

英文摘要：

Sphingosine-1-phosphate （S1 P） is a biologically active lysophospholipid messenger,which is mainly secreted by platelet and mastocyte and is important for cells＇growth,proliferation,migration and so on.Many studies have proved that S1P can protect heart,especially reduce the degreesof ischemia reperfusion injury during IR,which decreases the heart infarction and the occurrence of arrhythmia.S1P has the function of regulating vascular permeability and anti-atherosclerosis.S1 P biological effect involves varied signaling pathways,including Akt,ERK,Rho and so on.