中文摘要：

目的：环氧化酶2与肿瘤等血管生成性疾病关系密切，其抑制剂能抑制血管生成。本文就环氧化酶2及其抑制剂与血管生成性疾病的研究进展作一综述。资料来源：应用计算机检索PUBMED 1999-05／2005-12期间的相关文章，检索词为“cyclooxygenase-2，COX-2”，并限定文章语言种类为English。同时计算机检索万方数据库1977—12／2005—12期间的相关文章，检索词为“环氧化酶，血管生成”，并限定文章语言种类为中文。资料选择：对资料进行初审，并查看每篇文献后的引文。纳入标准：文章所述内容应与环氧化酶2及其抑制剂与血管生成性疾病研究相关。排除标准：重复研究或Meta分析类文章。资料提炼：共收集到423篇相关文献，16篇文献符合纳入标准，排除的407篇文献为内容陈旧或重复。符合纳入标准的16篇文献中，16篇涉及环氧合酶系统，8篇涉及环氧化酶2与血管生成性疾病研究，8篇涉及环氧化酶2调节血管生成的机制与信号通路，2篇涉及对环氧化酶2的展望。资料综合：环氧化酶2是炎症调节因子，与炎症、溃疡、脑卒中、神经变性疾病等关系密切。最近研究表明环氧化酶2是一个调控血管内皮生长因子表达的新基因，其下游产物PGI2与内皮收缩、血小板聚集有关，另一产物前列腺素E2是调控血管生成的开关。环氧化酶2抑制剂出现的心血管副作用更加表明重新评价环氧化酶2的重要性。结论：环氧化酶2及其抑制剂不仅与炎症性疾病有关，还与血管生成性疾病关系密切，靶向介导环氧化酶2下游通路的治疗策略将更有前途。

英文摘要：

OBJECTIVE： The cyclooxygenase-2 （COX-2） is closely correlated with the angiogenesis disease of tumor, the inhibitor of which can inhibit angiogenesis. In this article, the development in research on COX-2 and angiogenesis was reviewed. DATA SOURCES： A computer-based search was conducted in Pubmed for relevant articles published between May 1999 and December 2005 with the key words of ＂cyclooxygenase-2, COX-2＂, and the language was limited to English. Meanwhile, relevant Chinese articles between December 1977 and December 2005 were searched in Wanfang database with the key words of ＂cyclooxygenase-2, angiogenesis＂. STUDY SELECTION： Data were checked in the first trial, and the quotations at the end of each articles were looked for. Inclusion criteria： Articles related to COX-2, inhibitor of COX-2 and angiogenesis. Exclusion criteria： repetitive studies or Meta analytical studies. DATA EXTRACTION： Totally 423 relevant literatures were collected, and 16 studies were in accordance with the inclusion criteria. 407 old and repetitive literatures were excluded. Of 16 enrolled articles, 16 ones were involved in the COX system, 8 ones related to COX-2 and angiogenesis, 8 ones were about the mechanism and signal bypass of COX-2 in the regulation of angiogenesis and 2 literatures on the prospect of COX-2. DATA SYNTHESIS： As a muhifunctional inflammation modulator, COX-2 has been related tightly with neutodegenerative diseases, such as inflammation, ulceration, stroke and so on. Recent studies show that COX-2 is a new gene in regulating the expression of vascular endothelial growth factor, whose downstream product PGI2 is closely correlated with endothelial contraction and platelet aggregation, and COX-2-derived prostaglandin E2 regulates the angiogenesis. The cardiovascular side-effect of COX-2 significantly manifests that it is important to reevaluate the COX-2. CONCLUSION： COX-2 and its inhibitor not only relate with imflammatory diseases, but also closely correlate with angiogenesis diseases.