中文摘要：

目的分析有机溶剂中毒性脑病的临床诊治特点,并探索神经生长因子经鼻给药方法的可行性和安全性。方法回顾性分析15例经鼻给予神经生长因子治疗的有机溶剂中毒性脑病患者的临床特点,比较分析给药前后的实验室检验指标,同时记录不良事件。结果有机溶剂中毒性脑病患者症状表现为头晕、乏力等非特异性症状,以及记忆力下降、计算力下降等认知障碍。15例患者经鼻给药平均时间为14（9～31）d,治疗后2例有鼻黏膜轻微不适,其余未见异常。给药前后实验室指标比较,差异无统计学意义（P〉0.05）。结论有机溶剂中毒性脑病的诊断主要依据暴露史、临床表现及影像学检查综合判断,经鼻给予神经生长因子治疗有机溶剂中毒性脑病是一种安全、可行的方法。

英文摘要：

Objective To study the clinical characteristics of diagnosis and treatment for solvent-induced toxic encephalopathy and explore the feasibility and safety of intranasal administration with nerve growth factor （NGF） for the treatment of toxic encephalopathy. Methods The retrospective analysis was performed to analyze the clinical characteristics of 15 patients diagnosed with solvent-induced toxic encephalopathy and treated with NGF by intranasal administration. Then the comparative analysis was made to compare the laboratory test indexes before and after treatment, and the adverse events were also recorded. Results The main clinical manifestation in the patients with solvent-induced toxic encephalopathy involved the non-specific symptoms such as headache and fatigue and the cognitive disorders such as the deterioration of memory and computing power. The mean time of intranasal administration with NGF was 14 days with the range of 9 to 31 days. Only two patients felt slight discomfort of nasal mucosa. No significant differences were found in the laboratory test indexes between before and after treatment （P〉0.05）. Conclusion The diagnosis of solvent-induced toxic encephalopathy was mainly based on the exposure history, clinical manifestation and comprehensive judgement of neuroimaging examination. The intranasal administration with NGF is feasible and safe in treating the patients with toxic encephalopathy.