中文摘要：

针对微波消融治疗需要监测消融区域的温度变化状态和获取有效消融体积的问题,通过离体猪肝实验,分析了消融区域的温升规律并建立了微波消融有效消融体积的数学模型.共进行了112例离体猪肝实验,采用40～70 W的不同微波功率和300 ～ 600 s的不同作用时间进行微波消融.实验在70 W微波功率作用下,实时采集了距离微波消融针5、10、15、20 mm处的毁损区域温度,对采用不同微波功率和作用时间得到的有效消融区域的短径、长径及体积数据进行了分析,并利用1stopt软件进行拟合.结果显示,消融区域不同位置的升温速度不同,距离微波针5 mm位置的升温速度为20 mm处的10倍左右;得到了有效消融区域的短径、长径和体积有关微波功率和作用时间的离体组织数学模型.消融区域的温升状态监测和有效消融体积模型的建立,有助于优化微波消融的术前治疗计划和进行实时消融治疗的效果评估.

英文摘要：

Temperature variation in ablated area and effective ablation volume are very important parameters for microwave ablation treatment. In order to provide reference for real-time assessment of ablation efficacy, in vitro porcine liver experiments were carried out to monitor tissue temperature and build effective microwave ablation volume models in this work. Microwave power of 40 - 70 W and ablation time of 300- 600 s were chosen to perform total 112 microwave ablations. The microwave power of 70 W was used in the first group of experiments and temperature changes at sites 5, 10, 15 and 20 mm away from microwave antenna were recorded in real-time during ablation. In the second group of experiments, different combinations of power and time produced a series of data of short axis, long axis and volume. Results showed that the increase of temperature near the microwave antenna was more rapid. Temperature rise at 5 mm away from the antenna was l0 times faster than that at 20 mm away. Volume data of the ablation area was analyzed using 1 stopt to build experimental models for the short axis, long axis and volume of the ablation zone. Consequently, the monitoring of temperature and utilization of effective volume models will contribute to the microwave ablation surgical planning and real-time ablation efficacy assessment.