中文摘要：

银屑病的发病机制复杂,涉及到免疫、炎症等多个方面.趋化因子及其受体作为介导炎症及免疫反应的桥梁,参与自身免疫、感染、肿瘤和血管等多种疾病的病理过程.近年来,研究发现,银屑病患者存在多种趋化因子及其受体系统的异常表达,趋化因子及其受体通过一系列级联反应参与银屑病的发生发展.概述趋化因子及其受体在银屑病中的研究进展,以期在分子水平进一步探讨银屑病的发病机制.

英文摘要：

The pathogenesis of psoriasis is complex,and involves multiple factors such as immunity and inflammation.As one of the mediators of inflammation and immune response,chemokines and their receptors participate in the pathological process of many diseases,such as autoimmune diseases,infection,tumor and vascular diseases.Recently,it has been revealed that many chemokines and their receptors are abnormally expressed in patients with psoriasis,which may be involved in the formation and development of psoriasis via a series of cascade reactions.This paper presents recent advances in the research about chemokines and their receptors in psoriasis,in order to further elucidate the pathogenesis of psoriasis at the molecular level.