中文摘要：

CoQ 是在 mitochondrial 的一个必要电子搬运人优核质和初核质的呼吸的链。它由一个 benzoquinone 头组和一条恐水病的 polyisoprenoid 尾巴组成。涉及 CoQ 生合成的基因(COQ19 ) 在酵母被描绘了。在这研究，我们产生了并且分子地描绘了新奇果蝇基因的变异的等位基因， sbo，它编码被预言在 CoQ 的过程期间与 isoprenoid 链催化 p-hydroxybenzoate 的 prenylation 的蛋白质合成。在酵母的 sbo 的表示救 COQ2 变异的房间的致命性，显示 sbo 是 COQ2 的一个功能的相当或相同的事物。HPLC 结果证明 CoQ9 和 CoQ10 的层次显著地在异质接合的成年人飞的 sbo 被减少。而且，男性和为 sbo 异质接合的女性的吝啬的 lifespans 被 12.5% 和 30.8% 分别地扩大。同型结合的 sbo 动物展出发信号的 insulin/insulin-like 生长因素(IIS ) 的减少的活动小径。一起拿，我们断定 sbo 是为果蝇开发的必要基因，哪个由改变内长的 CoQ 生合成很可能导致 lifespan 的延期的变化。

英文摘要：

CoQ is an essential electron cartier in the mitochondrial respiratory chain of both eukaryotes and prokaryotes. It consists of a benzoquinone head group and a hydrophobic polyisoprenoid tail. The genes （COQ1-9） involved in CoQ biosynthesis have been characterized in yeast. In this study, we generated and molecularly characterized a mutant allele of a novel Drosophila gene, sbo, which encodes a protein that is predicted to catalyze the prenylation of p-hydroxybenzoate with the isoprenoid chain during the process of CoQ synthesis. Expression of sbo in yeast rescues the lethality of ACOQ2 mutant cells, indicating that sbo is a functional homolog of COQ2. HPLC results show that the levels of CoQ9 and COQlo were significantly reduced in sbo heterozygous adult flies. Furthermore, the mean lifespans of males and females heterozygous for sbo are extended by 12.5% and 30.8%, respectively. Homozygous sbo animals exhibit reduced activities of the insulin/insulin-like growth factor signaling （IIS） pathway. Taken together, we conclude that sbo is an essential gene for Drosophila development, mutation of which leads to an extension of lifespan most likely by altering endogenous CoQ biosynthesis.