目的 探讨老年心肌梗死后慢性心力衰竭(CHF)患者心室结构-心电重构与心律失常的关系。方法 收集老年心肌梗死后CHF患者55例[心功能(NYHA分级):Ⅱ级23例,Ⅲ级15例,Ⅳ级17例]及心肌梗死后心功能(NYHA)Ⅰ级患者30例,采用超声心动图,标准12导联心电图及24小时动态心电图检测其心室腔大小,QT间期,校正QT间期(QTc)及心律失常。结果 与心功能I级组比较,CHF组心室腔显著扩大[CHF组:左室舒张末直径(LVEDD)(57±8)mm,左室收缩末直径(LVESD)(45±8)mm;心功能Ⅰ级组:LVEDD(45±5)mm,LVESD(31±5)mm,P〈0.05]。两组间心室复极指标无显著差异[CHF组:QT(0.41±0.07)s,QTc(0.44±0.06)s;心功能Ⅰ级组:QT(0.41±0.04)s,QTc(0.44±0.04)s]。两组间室性心律失常亦无显著差异[CHF组:室性早搏(VPB)(219±598)次/24h;心功能Ⅰ级组:VPB(345±504)次/24h]。结论 老年心肌梗死后CHF时,心室结构重构显著,心 室腔显著扩大,但在本研究中心室结构重构未见引起显著心电重构,心室复极延长及室性心律失常未见显著增加。
AIM To investigate the relation between ventricular structural electrocardiological remodeling and ventricular arrhythmia in elderly patients with chronic congestive heart failure (CHF) secondary to old myocardial infarction. METHODS Fifty-five elderly patients with CHF secondary to old myocardial infarction (23 in cardiac function class Ⅱ, 15 in class Ⅲ, 17 in class Ⅳ, NYHA ) and in 30 agematched elderly patients with cardiac function class Ⅰ (NYHA) secondary to old myocardial infarction were included in this study. Their ventricular chamber sizes, QT, QTc intervals and the ventricular arrhythmia were assessed respectively with echocardiography, standard 12-lead electrocardiography and 24- hour Hoher recordings. RESULTS The ventricular chamber sizes were significantly larger in the elderly patients with CHF than those in cardiac function class I group [ CHF group: left ventricular end diastolic diameter (LVEDD) (57 ± 8 ) ram; left ventricular end systolic diameter (LVESD) (45 ± 8 ) mm vs. cardiac function class Ⅰgroup: LVEDD (45 ± 5 )mm; LVESD ( 31± 5 ) mm, P 〈 0.05, respectively ]. However, there was no difference in ventricular repolarization indices between the two groups [ CHF group: QT ( 0.41±0.07) s; QTc ( 0.44±0.06) s vs. cardiac function class Ⅰ group: QT (0.41 ± 0.04 ) s, QTc (0.44 ± 0.04) s, respectively ]. The ventricular arrhythmogenesis was also not found to be significantly higher in the elderly patients with CHF than those in cardiac function class Ⅰ group [ CHF group: ventricular premature beat (VPB) (219 ±598)1/24 h vs. cardiac function class Ⅰ group: VPB(345 ± 504)1/24 h ]. CONCLUSION The ventricular structural remodeling enlargement is significant in elderly patients with CHF secondary to old myocardial infarction. However, the ventricular structural re-modeling enlargement does not cause significant prolongation of the ventricular repolarization and the increase of the ventricular arrhythmo