欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
单个粒子的追踪的用光使敏化的本地化显微镜学(sptPALM ) 最近为高密度的成像作为一个强大的工具出现了并且在生活房间单个分子追踪。在这个工作，我们在两个都使用传统的单个粒子的追踪的高表示水平(SPT ) 和 sptPALM 监视了并且比较 TGF- 类型 II 受体(TRII ) 的散开动力学。TRII oligomers 的导致 ligand 的聚集被 sptPALM 进一步显示。由于在衍射限制以内区分并且追踪单个分子的能力， sptPALM 由提供更精确的生物物理的信息超过传统的 SPT。
英文摘要：
Single-particle tracking photoactivated local- ization microscopy （sptPALM） has recently emerged as a powerful tool for high-density imaging and tracking of individual molecules in living cells. In this work, we have monitored and compared the diffusion dynamics of TGF-β type II receptor （TβRII） at high expression level using both traditional single-particle tracking （SPT） and sptPALM. The ligand-induced aggregation of TβRII oligomers was further indicated by sptPALM. Due to the capacity of distinguishing and tracking single molecules within diffraction limit, sptPALM outperforms traditional SPT by providing more accurate biophysical information,
同期刊论文项目
同项目期刊论文
Internalization of the TGF-β type I receptor into caveolin-1 and EEA1double-positive early endosomes
A New Microfluidic Chip-Based Online Electrochemical Platform for Extracellular Neurochemicals Monit
In vivo ratiometric Zn2+ imaging in zebrafish larvae using a new visible light excitable fluorescent
A simple and versatile microfluidic cell density gradient generator for quantum dot cytotoxicity ass
Colorimetric and Fluorescent Dual Mode Sensing of Alcoholic Strength in Spirit Samples with Stimuli-
A multi-enzyme microreactor-based online electrochemical system for selective and continuous monitor
An H2O2-responsive nanocarrier for dual-release of platinum anticancer drugs and O-2: controlled rel
Continuous and Simultaneous Electrochemical Measurements of Glucose, Lactate, and Ascorbate in Rat B
Statistical single-cell analysis of cell cycle-dependent quantum dot cytotoxicity and cellular uptak
Online monodisperse droplets based liquid-liquid extraction on a continuously flowing system by usin
Strategy for signaling molecule detection by using an integrated microfluidic device coupled with ma
Platinum(II)-Gadolinium(III) Complexes as Potential Single-Molecular Theranostic Agents for Cancer T
Single-molecule dynamics of site-specific labeled transforming growth factor type II receptors on li
Visualization of the post-Golgi vesicle-mediated transportation of TGF-beta receptor II by quasi-TIR
Interfacing Microsampling Droplets and Mass Spectrometry by Paper Spray Ionization for Online Chemic
High-throughput and automatic typing via human papillomavirus identification map for cervical cancer
A portable microchip for ultrasensitive and high-throughput assay of thrombin by rolling circle ampl
A mitochondrion-targeting copper complex exhibits potent cytotoxicity against cisplatin-resistant tu
A turn-on fluorescent Fe3+ sensor derived from an anthracene-bearing bisdiene macrocycle and its int
Visualization and quantification of neurochemicals with gold nanoparticles: Opportunities and challe
Water-Stable, Adaptive, and Electroactive Supramolecular Ionic Material and Its Application in Biose
An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass sp
Aggregation-Induced Structure Transition of Protein-Stabilized Zinc/Copper Nanoclusters for Amplifie
Assay of multiplex proteins from cell metabolism based on tunable aptamer and microchip electrophore
Nanoscale imaging with an integrated system combining stimulated emission depletion microscope and a
Internalization of the TGF-beta type I receptor into caveolin-1 and EEA1 double-positive early endos
Online electrochemical systems for continuous neurochemical measurements with low-potential mediator
期刊信息
位置：