中文摘要：

重离子在放射肿瘤学方面的应用和人类太空探索的发展，极大地促进了重离子辐射生物学研究。染色体畸变是典型的辐射损伤生物标志物。本工作就重离子辐射诱导哺乳动物染色体畸变研究进展进行评述。

英文摘要：

The application of heavy-ions in radiation oncology and the development of human space exploration have greatly contributed to the heavy-ions radiobiology. Chromosomal aberration is a typical biomarker of radiation damage. The progresses obtained in mammalian cells chromosome aberrations induced by heavy-ions have been reviewed in this paper.