中文摘要：

目的探讨静脉给予ilexgenin A后大鼠体内的药物动力学特征。方法采用HPLC测定大鼠血浆中的血药浓度,用DAS 2.0药动学软件求算其药动学参数。结果 Ilexgenin A在大鼠体内呈二室模型分布,主要药动学参数为：t1/2α=0.545min,t1/2β=18.338 min,Cl=0.019 L·min-1.kg-1,AUC0→t=2.5902 g·min·L-1。结论所用方法可用于大鼠血浆中ilexgeninA的检测及其体内药动学研究;静脉给药后,ilexgenin A在大鼠体内分布和消除迅速。

英文摘要：

OBJECTIVE To study the pharmacokinetics of ilexgenin A in rats after intravenous injection.METHODS HPLC was used,and parameters of pharmacokinetics were calculated by DAS 2.0 software.RESULTS The blood plasma concentration-time course was fitted with 2-compartment model.The pharmacokinetic parameters were as following：t1/2α=0.545 min,t1/2β=18.338 min,Cl=0.019 L·min-1·kg-1,AUC0→t=2.5902 g·min·L-1.CONCLUSION The HPLC method is appropriate for the determination and pharmacokinetic study of ilexgenin A in rat plasma.Ilexgenin A is distributed and eliminated quickly in rats.