东篱科研大数据发现系统（DRDS）

位置：成果数据库 > 期刊 > 期刊详情页

Construction of Soluble Mamu-B＊1703, a Class I Major Histocompatibility Complex of Chinese Rhesus Macaques, Monomer and Tetramer Loaded with a Simian Immunodeficiency Virus Peptide

ISSN号：1672-7681
期刊名称：《中国免疫学杂志：英文版》
时间：0
分类：Q95[生物学—动物学]
作者机构：[1]Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China, [2]Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China, [3]Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunrning Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China, [4]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China
相关基金：This work was supported by the grants from the National Natural Science Foundation of China （No. 30572199, No. 30230350 and No. 30371651） to Prof. XH He; the Talented Man Initiation Fund of Jinan University （No. 51208004 and No. 51208017） and Natural Science Fund of Guangdong Province （No. 8451063201000340） to Dr. DY Ouyang; the Scientific and Technological Projects of Yunnan （2004NG12 and 2006PT08）, the Major State Basic Research Development Program of China （2006CB504208）, the Knowledge Innovation Program of CAS （KSCX1-YW-R-15） to Dr. YT Zheng, and ＂Western Light＂ Projects to Dr. GH Zhang; as well as by the Biochemistry and Molecular Biology Key Discipline of Guangdong Province; Acknowledgements We thank Dr. Natasja de Groot, Dr. Nel Otting and IMGT Nonhuman Primate Nomenclature Committee for naming the Mamu-A and Mamu-B sequences.

作者： Dongyun Ouyang[1], Xiaoying Wang[1], Xianhui He[1], Lihui Xu[2], Huanjing Shi[1], Qi Gao[1], He Guo[1]

关键词：中国, 猕猴, 等位基因, 组织相容性, Mamu-A, Mamu-B, MHC class I, rhesus macaque

中文摘要：

主要 histocompatibility 建筑群(MHC ) 一级信息为在 HIV 种痘和生物医学的模型理解有免疫力的回答的变化是重要的。在这研究， 9 Mamu -- A 和 13 Mamu-B 等位基因从 10 只中国起源的罗猴猕猴的 cDNA 产品被识别。除了被其它报导了的二等位基因，八是新奇的， 12 扩大了在 GenBank 是可得到的部分序列。MHC 一级抗原的另外的信息可能对在人的疾病研究的中国猕猴的可获得性有益。而且，领先的肽的多型性和在 α1 领域的自然漂亮受体识别主题两个都暗示那 Mamu -- A 和 Mamu-B 分子力量玩在自然漂亮房间的天生的有免疫力的回答给角色调音。

英文摘要：

Major histocompatibility complex （MHC） class I information is vital for understanding variance of immune responses in HIV vaccination and biomedical models. In this study, 9 Mamu-A and 13 Mamu-B alleles were identified from the cDNA products of 10 Chinese-origin rhesus macaques. Except for two alleles that had been reported by others, eight were novel and twelve extended the partial sequences that are available in GenBank. The additional information of MHC class I antigens might be beneficial to the availability of Chinese macaques in human disease studies. Furthermore, the polymorphism of leading peptides and the natural killer receptor recognition motifs in al domain both implies that Mamu.A and Mamu-B molecules might play key roles in innate immune responses of natural killer cells.

同期刊论文项目