中文摘要：

电化学疗法是将电穿孔与化学药物相结合治疗肿瘤的一种新方法，电穿孔可通过脉冲电场瞬时提高细胞膜的通透性使药物等外源物质进入细胞，增强细胞对药物的吸收能力，从而提高治疗肿瘤的效果。我们采用LN-101基因脉冲导入仪及配套的针电极，通过电化学疗法对接种有S-180的小鼠进行对比实验。结果应用抗癌药物博莱霉素（BLM）的电化学疗法（ECT）组的抑瘤率为70.4％，与传统的治疗方法相比抑瘤率显著提高。

英文摘要：

Electrochemotherapy （ECT） is a new efficient approach which treats tumor by electroporation and chemotherapeutic agents. Electroporation can deliver exogenous molecules such as drugs into cell by pulsed electric fields through a temporary increase in cell membrane permeability. It results in much higher uptake of the drugs and better effect of antitumoral treatment. We have performed the experiments on mice inoculated S-180 using gene pulse ransfection apparatus LN-101 and needle electrodes combined with antitumor drugs. Inhibitory rates of ECT with antitumor drugs Bleomycin（BLM） is 70.4%, and is enhanced significantly in contrast to other methods in the experiments.