中文摘要：

嵌合抗原受体修饰的T细胞（CAR-T）是一种安全有效的肿瘤治疗策略。在多种血液肿瘤的临床试验中,CAR-T细胞疗法取得重大突破,在实体瘤的临床试验中也崭露头角。但在获得显著疗效的同时,CAR-T也存在脱靶效应、细胞因子风暴、插入突变、对实体肿瘤疗效有限等问题。现就CAR-T技术的最新进展及该领域有待解决的问题进行综述,为CAR-T疗法的进一步研究和临床应用提供参考。

英文摘要：

A lot of remarkable results suggested that the modification of T-cells with CARs（CRA-T） could be a powerful approach for developing safe and effective cancer therapeutics. A novel breakthrough has been made in CAR-T treatment of hematologic tumors and therapeutic potential in clinical studies of solid tumors has been achieved,although there are still many problems for CAR-T on the clinical application such as off-target effects,cytokine storm,insertion mutagenesis,limited effects for solid tumors. Here,we reviewed the recent advances of CAR-T and problems that need to be solved in this field,which provide references for the in-depth study and further clinical immunotherapy.