中文摘要：

RD-1（region of difference-1）被认为在结核分枝杆菌（Mycobacterium tuberculosis,MTB）的致病机理中起着关键的作用.RD-1基因全长9.5kb,开放读码框从Rv3871～Rv3879c,分别编码9种不同的蛋白质.RD-1区在卡介苗（bacillusCalmette-Guerin,BCG）中是缺失的.研究结果显示,RD-1区是结核分枝杆菌的主要毒力因素之一,同时RD-1区参与了一种新的分泌系统ESX-1,这种分泌系统能够促进某些特定蛋白的分泌.ESX-1分泌的两种主要蛋白质CFP-10（culture filtrateprotein of10ku）和ESAT-6（early secreted antigenic target of6ku）能够形成牢固的1∶1的复合体,这两种蛋白质能够协同分泌而且能够引起T细胞反应,并可能作为理想的靶抗原在结核的预防和诊断中发挥作用.

英文摘要：

The RD-1 locus has been considered crucial in the pathogenesis of M. tuberculosis, the RD-1 locus is 9.5 kb and spanning open reading frames Rv3871 to Rv3879c encoding 9 different proteins separately. The RD-1 locus is missing in all bacillus Calmette-Guerin （BCG） strains, and is one of the key virulence factor in M. tuberculosis. The RD-1 locus participates in a new secreting system named ESX-1, which can facilitate the secretion of some special proteins. The two important proteins encoded by the RD-1 locus named CFP-10 and ESAT-6 can form a tight 1 ： 1 complex, and has been shown to be coordinately secreted and lead to a strong T cell response, which suggests that these two proteins may act as ideal target antigens in diagnosis and prevention of tuberculosis （TB）.