中文摘要：

目的：研究五味子醇甲对β-淀粉样蛋白（amyloidβ-protein,Aβ）损伤大鼠肾上腺髓质嗜铬瘤细胞（PC12细胞）的预保护及治疗作用。方法：体外培养PC12细胞,建立Aβ引起的细胞损伤模型;采用细胞形态学观察突起长度及神经网络的变化,细胞形态学定量测定有突起的细胞数目,MTT法测定细胞活性。结果：细胞形态学、细胞形态学定量和细胞活性测定结果表明,与Aβ模型组比较,五味子醇甲低、中、高剂量（1、3、9μg/mL）组PC12细胞神经突起较长,神经网络破坏的程度较轻,有突起细胞数目增多,细胞活性增高。结论：五味子醇甲具有拮抗Aβ神经毒性的作用,对Aβ损伤PC12细胞具有预保护及治疗作用。

英文摘要：

Objectives：To observe the protective and therapeutic effect of schisandrol A on the Aβ damaged PC12 cells.Methods：PC12 cells were damaged by Aβ in vitro.Morphological changes were observed and the number of cells with neurite was analyzed by phase contrast microscope.The cell viability of PC12 eclls was determined by the MTT method.Results：Many dispirited cells with atrophied or fragmented neurites in the Aβ damaged PC12 cells were observed under the microscope.More vital cells with longer neurites were observed in the schisandrol A treated PC12 cells and the number of cells with neurite increased.The difference of cell viability between the two groups was statistical significant.Conclusion：Schisandrol A can antagonize the neurotoxicity of Aβ,and has protective and therapeutic efficacy on Aβ damaged PC12 cells.