新陈代谢的 reprogramming 是在癌症的批评特征之一。肿瘤房间优先地相反利用 glycolysis ofoxidative phosphorylation 面对氧,也就是 Warburg 效果。最近的研究提供了新卓见 intothe Warburg 效果,阐明 post-translationalmodifications 和提供的进一步的证据在癌症新陈代谢和 tumorigenesis.Of 详细规格为这些诡计的关键角色调整的新陈代谢的酶的新陈代谢依赖者、独立的机制感兴趣,我们在两个总结了最近的进展新陈代谢并且经由在 Warburg 的 acetylation 规定的 metabolicenzymes 的非新陈代谢的功能完成。另外,他们在癌症新陈代谢 therapywill 的潜在的角色简短也被讨论。
Metabolic reprogramming is one of the critical features in cancer. Tumor cells preferentially utilize glycolysis instead of oxidative phosphorylation in the presence of oxygen, namely 'Warburg Effect'. Recent studies have provided new insights into the Warburg effect, elucidating metabol- ic-dependent and independent mechanisms of metabolic enzymes regulated by post-translational modifications and providing further evidence for the critical role of these tricks in cancer metabolism and tumorigenesis. Of particu- lar interest, we summarized the latest advances in both the metabolic and the non-metabolic functions of metabolic enzymes via the acetylation regulation in the Warburg effect. In addition, their potential roles in cancer metabol- ism therapy will also be briefly discussed.