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Acetylation control of metabolic enzymes in cancer: an updated version
  • ISSN号:1672-9145
  • 期刊名称:《生物化学与生物物理学报:英文版》
  • 时间:0
  • 分类:Q5-4[生物学—生物化学] S435.112.3[农业科学—农业昆虫与害虫防治;农业科学—植物保护]
  • 作者机构:[1]Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China, [2]Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China, [3]Department of Biological Sciences, Harper Cancer Research Institute, University of Notre Dame, South Bend, IN 46617, USA, [4]School of Life Science, Fudan University, Shanghai 200032, China
  • 相关基金:This work was supported by 973 grants (2009CB918401 and 2011CB910600), NSFC (31271454, 81225016, and 31071192), Shanghai Key basic Research Program (12JC1401100), 100 Talents Program of Shanghai Health (XBR2011041), the Dawn Program of Shanghai Education Commission, and the Program for the Shanghai Outstanding Academic Leader (13XD1400600) to Q.Y.L. This work was also supported by the 985 Program, the Shanghai Leading Academic Discipline Project (B110). This work is dedicated to the memory ofZhen Yu, who prepared the site(s)-specific acetylati0n antibodies.
中文摘要:

新陈代谢的 reprogramming 是在癌症的批评特征之一。肿瘤房间优先地相反利用 glycolysis ofoxidative phosphorylation 面对氧,也就是 Warburg 效果。最近的研究提供了新卓见 intothe Warburg 效果,阐明 post-translationalmodifications 和提供的进一步的证据在癌症新陈代谢和 tumorigenesis.Of 详细规格为这些诡计的关键角色调整的新陈代谢的酶的新陈代谢依赖者、独立的机制感兴趣,我们在两个总结了最近的进展新陈代谢并且经由在 Warburg 的 acetylation 规定的 metabolicenzymes 的非新陈代谢的功能完成。另外,他们在癌症新陈代谢 therapywill 的潜在的角色简短也被讨论。

英文摘要:

Metabolic reprogramming is one of the critical features in cancer. Tumor cells preferentially utilize glycolysis instead of oxidative phosphorylation in the presence of oxygen, namely 'Warburg Effect'. Recent studies have provided new insights into the Warburg effect, elucidating metabol- ic-dependent and independent mechanisms of metabolic enzymes regulated by post-translational modifications and providing further evidence for the critical role of these tricks in cancer metabolism and tumorigenesis. Of particu- lar interest, we summarized the latest advances in both the metabolic and the non-metabolic functions of metabolic enzymes via the acetylation regulation in the Warburg effect. In addition, their potential roles in cancer metabol- ism therapy will also be briefly discussed.

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期刊信息
  • 《生物化学与生物物理学报:英文版》
  • 北大核心期刊(2004版)
  • 主管单位:
  • 主办单位:中国科学院上海生物化学研究所
  • 主编:
  • 地址:上海岳阳路319号
  • 邮编:200031
  • 邮箱:abbs@sibs.ac.cn
  • 电话:021-54920956 54920955
  • 国际标准刊号:ISSN:1672-9145
  • 国内统一刊号:ISSN:31-1940/Q
  • 邮发代号:4-210
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引(扩展库),美国生物科学数据库,英国动物学记录,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),英国英国皇家化学学会文摘,中国北大核心期刊(2000版)
  • 被引量:5851