中文摘要：

以α-氰基肉桂酸乙酯衍生物、酰胺和N-溴代丁二酰亚胺（NBS）为原料，在无水碳酸钠促进下，以N，N-二甲基甲酸胺（DMF）为溶剂，室温下建立了三组分合成2-噁唑啉的新体系.在优化条件下，丙酰胺、丙烯酰胺、异丁酰胺和戊酰胺均能与不同结构的α-氰基肉桂酸乙酯衍生物反应，高收率地生成相应的2-噁唑啉（最高收率可达94%），说明该反应具有广泛的适应性.合成了39个新化合物，其结构均由核磁共振氢谱、碳谱和高分辨质谱确证.根据实验结果，提出了该反应的可能机理，该机理有力地支持了形成2-噁唑啉时的区域选择性.

英文摘要：

An easy and efficient new method for the three-component synthesis of 2-oxazolines from ethyl α-cyanocinnamate derivatives with amide and N-bromosuccinimide has been developed. A series of ethyl α-cyanocinnamate derivatives can be smoothly con-verted into corresponding 2-oxazoline derivatives promoted by Na2CO3 in N,N-dimethylformamide （DMF） at room temperature in high yield （up to 94%）. The reactions of 11 structurally different substrates with propionamide, acrylamide, isobutyamide and pentanamide were investigated, respectively. The results indicated that the protocol has applicability in a large scope of ethyl α-cyanocinnamate derivatives and amides. A possible mechanism was proposed and it can explain well the full regiospecificity of the reaction. 39 new compounds were achieved via the three-component synthesis reaction and all the products structures were confirmed by their ^1H NMR, ^13C NMR and HRMS analysis.