中文摘要：

这个工作的目的是开发 alginate 酷蛋白合成的 microsphere 作为为由简单挤出的营养素的口头的管理的 bioactive 车辆滴下方法。核黄素作为模型药被选择，并且 microencapsulation 效率在由反应表面方法论优化准备条件以后被提高到 97.94% 。在 vitro，版本研究证明核黄素在模仿的肠的液体完全被免除 alginate 酷蛋白 microspheres。同时，在 alginate 和酷蛋白之间的形态学，结构和相互作用被扫描电子显微镜学(SEM ) 和 Fourier 变换描绘红外线(FTIR ) 系列。

英文摘要：

The aim of this work was to develop an alginate-casein composite microsphere as a bioaetive vehicle for oral administration of nutrients by a simple extrusion dripping method. Riboflavin was selected as a model drug, and the microencapsulation efficiency was raised to 97.94% after optimizing the preparation conditions by response surface methodology. In vitro release studies showed that riboflavin was released completely from alginate-casein microspheres in simulated intestinal fluids. Meanwhile, the morphology, structure and interaction between alginate and casein were characterized by scanning electron microscopy （SEM） and Fourier transform infrared （FTIR） spectra.