中文摘要：

近年来,糖尿病的患病率明显升高,机制尚不清楚。研究发现,持久性有机污染物（POP）可能是导致糖尿病发生的原因之一。本文对POP的概念、种类及其导致糖尿病的相关机制进行综述,并从胰岛素分泌、胰岛素抵抗及表观遗传学3个方面对POP与糖尿病的关系进行探讨,推测POP通过升高血清γ谷氨酰转移酶水平影响胰岛素分泌;也可通过抑制葡萄糖转运蛋白4表达造成胰岛素抵抗;除此之外,POP可通过改变组蛋白修饰、DNA甲基化和微小RNA（miRNA）的水平等表观遗传修饰导致糖尿病的发生。

英文摘要：

Without clear pathogenesis, diabetes is becoming more prevalent in recent years. Many studies have found that persistent organic pollutants （POP） may be one of the possible causes of diabetes. This review elaborates on the concepts and types of POP, their role in diabetes, and the relationship between POP and diabetes in terms of insulin secretion, insulin resistance and epigenetics. We hypothe- size that POP can affect insulin secretion by increasing the y-glutamyl transpeptidase level and cause insulin resistance by decreasing the glucose transporter type 4 level, Besides, POP may result in the occurrence of diabetes by changing epigenetic modification including histone modification and the level of DNA methylation and microRNA（miRNA）.