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New strategies against drug resistance to herpes simplex virus
  • ISSN号:1674-2818
  • 期刊名称:《国际口腔科学杂志:英文版》
  • 分类:S858[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医] Q78[生物学—分子生物学]
  • 作者机构:[1]State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China, [2]XiangYa Stomatological Hospital, Central South University, Changsha, China, [3]Center for Nanotechnology, Munster, West China Medical School, Sichuan University, Chengdu, China, [4]Germany and Institute for Nanobiomedical Technology and Membrane Biology, West China Medical School, Sichuan University, Chengdu, China
  • 相关基金:We thank the National Natural Science Foundations of China (document no. 81321002, 81500860, 81300888) and a grant from 111 Project of Ministry of Education, China, for financial support.
中文摘要:

Herpes simplex virus(HSV),a member of the Herpesviridae family,is a signi fi cant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections.Acyclovir(ACV)and related nucleoside analogues can successfully treat HSV infections,but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections,especially in immunocompromised patients.There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV.This review summarises the current strategies in the development of new targets(the DNA helicase/primase(H/P)complex),new types of molecules(nature products)and new antiviral mechanisms(lethal mutagenesis of Janus-type nucleosides)to fi ght the drug resistance of HSV.

英文摘要:

Herpes simplex virus (HSV), a member of the Herpesviridae family, is a significant human pathogen that results in mucocutaneous lesions in the oral cavity or genital infections. Acyclovir (ACV) and related nucleoside analogues can successfully treat HSV infections, but the emergence of drug resistance to ACV has created a barrier for the treatment of HSV infections, especially in immunocompromised patients. There is an urgent need to explore new and effective tactics to circumvent drug resistance to HSV. This review summarises the current strategies in the development of new targets (the DNA helicase/primase (H/P) complex), new types of molecules (nature products) and new antiviral mechanisms (lethal mutagenesis of Janus-type nucleosides) to fight the drug resistance of HSV.

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期刊信息
  • 《国际口腔科学杂志:英文版》
  • 主管单位:教育部
  • 主办单位:四川大学
  • 主编:周学东
  • 地址:成都市一环路南一段24号
  • 邮编:610041
  • 邮箱:ijos@scu.edu.cn
  • 电话:028-85502414
  • 国际标准刊号:ISSN:1674-2818
  • 国内统一刊号:ISSN:51-1707/R
  • 邮发代号:62-324
  • 获奖情况:
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,波兰哥白尼索引,荷兰文摘与引文数据库,美国生物医学检索系统,美国剑桥科学文摘,美国科学引文索引(扩展库)
  • 被引量:21