中文摘要：

有效运载和传递生长因子以调控细胞在支架上的生长行为是组织工程研究中的一个关键问题。高分子纳米粒子是包载生长因子的候选载体之一。介绍了组织工程研究中若干常用生长因子的生物学特性，对包载生长因子用的高分子材料的种类及其纳米粒子的制备方法进行了总结，分析了不同种类材料和制备工艺的优势与缺点；并在此基础上对多种包载生长因子的高分子纳米粒子的研究现状和发展趋势作了综合评述和展望。

英文摘要：

Effective loading and site-specific delivery of growth factors to regulate the cell growth on scaffold is one of the key issues of tissue engineering. Polymeric nanoparticle is one of the candidate carriers for carrying growth factor. This article attempts to introduce the biological characteristics of growth factors commonly used in tissue engineering, polymer materials for carrying the growth factors and the preparation of the nanoparticles and delivery systems. The advantages and disadvantages of different preparations are also discussed to facilitate the selection of the appropriate methods and materials. Relevant research progress and application potentials are discussed as well.