中文摘要：

学习的目的是在聚类家庭的鼻咽的癌(NPC ) 的成员观察与染色体稳定性和 DNA 修理有关的基因的表情的目的。有的中山城市里的方法高度 NPC 的发生率，我们选择了作为鼻咽炎的目标，和病人聚类家庭的 NPC 和 NPC 的成员为控制组。我们从鼻咽的织物孤立 RNA，并且综合它的 cRNA，染色体稳定性和 DNA 修理基因薄片技术， chemiluminescent 察觉和即时荧光量的技术被用来在鼻咽的织物检验染色体稳定性和 DNA 修理基因。结果更多的染色体稳定性和 DNA 修理基因在比 NPC 病人，和范围聚类家庭的 NPC 的成员是起来调整的起来调整高，与过去起来调整的 100 次基因包括 TEP1， MSH4， PMS2L1。更少染色体稳定性和 DNA 修理基因在比 NPC 病人，聚类家庭的 NPC 的成员是下面调整的 ubiquitin 基因几乎是下面调整的，结果能被即时荧光也证实量的 PCR。在那里的结论是特殊在聚类家庭的 NPC 的成员的染色体稳定性和 DNA 修理基因的表达式特性。

英文摘要：

Objective： The aim of the study was to observe the expressions of genes related to genome stability and DNA repair in the members of nasopharyngeal carcinoma （NPC） clustedng families. Methods： In the Zhongshan City where there is highly incidence rate of NPC, we chose the members of the NPC clustering families as objects, and the patients of nasopharyngitis and NPC as the control group. We isolated the RNA from the nasopharyngeal tissue, and synthesized its cRNA, the genome stability and DNA repair genes chip technique, chemiluminescent detection and real-time fluorescence quantita- tive technique were used to examine the genome stability and DNA repair genes in the nasopharyngeal tissue. Results： More genome stability and DNA repair genes were up-regulated in the members of the NPC clustering families than the NPC patients, and the range of up-regulated was high, with the over up-regulated 100 times genes including TEP1, MSH4, PMS2LI. Fewer genome stability and DNA repair genes were down-regulated in the members of the NPC clustering families than the NPC patients, the ubiquitin genes almost were down-regulated, the results also could be confirmed by real-time fluorescence quantitative PCR. Conclusion： There are specially expression character of genome stability and DNA repair genes in the members of NPC clustering families.