中文摘要：

病毒入侵是病毒感染宿主细胞的第一步,涉及病毒与宿主细胞受体的结合、膜融合等过程,而这些过程是由病毒的囊膜蛋白所介导。已知昆虫杆状病毒中存在GP64和F 2种不同类型的囊膜蛋白。感染鳞翅目昆虫的核型多角体病毒（NPV）中的GroupⅠ组病毒同时具有F蛋白和GP64蛋白的同源物,但是F蛋白不是膜融合蛋白;GroupⅡ组NPV和颗粒病毒（GV）以及感染双翅目昆虫的病毒仅有F蛋白的同源物,而在感染膜翅目昆虫的病毒中,这2种蛋白质的同源物均不存在。F蛋白又可分为Fa和Fb 2类。在GroupⅡ组NPV中,Fa是出芽型病毒粒子的膜融合蛋白,能介导低p H依赖的膜融合;而在GroupⅠ组NPV中,Fb蛋白的功能目前尚不明确,其膜融合活性被认为在进化历程中被GP64所取代。本文重点综述昆虫杆状病毒囊膜蛋白F的研究进展。

英文摘要：

Viral entry is the first key step for virus infection, which involves receptor binding and membrane fusion media- ted by viral envelope proteins. In the family Baculoviridae, two different envelope proteins named GP64 and F have been identified. Group I NPVs （ nuclear polyhedron viruses） which can infect Lepidoptera insects have homologs of both GP64 and F, but F is not a membrane fusion protein. Group II NPVs, GVs （granulosis virus） and viruses hostile to Diptera in- sects only have homologs of F, whereas the viruses corresponding to hymenoptera insects have homologs of neither GP64 nor F. F protein is divided into two categories, Fa and Fb. Fa is an membrane fusion protein of budded virion in Group II NPVs. It can mediate Iow-pH-dependent membrane fusion. In Group I NPVs, the function of Fb has not been e- lucidated and its fusion activity is speculated to be replaced by GP64 during evolution. This article reviews major research progress in envelope protein F of baculovirus.