中文摘要：

目的观察不同证型银屑病患者血清血管内皮生长因子（vascular endothelial growth factor，VEGF）水平的差异及理血解毒类方对银屑病患者血清VEGF的调节作用，探讨银屑病的病机基础及中医药作用机制。方法采用酶联免疫吸附法检测105例寻常型银屑病（血热型、血燥型、血瘀型）患者口服凉血解毒汤、养血解毒汤和活血解毒汤前后血清VEGF水平。结果银屑病组患者治疗前血清VEGF水平较正常对照组显著升高，差异有统计学意义（P〈0．01），治疗前血热型银屑病组患者血清VEGF显著高于血燥型组，差异有统计学意义（P〈0．05）；与血瘀型组相比差异无统计学意义；血燥型银屑病组患者与血瘀型组患者相比血清VEGF差异亦无统计学意义。与治疗前比较，血热型和血燥型银屑病组经中药治疗后血清VEGF均明显降低（P〈0．05），血瘀型银屑病组患者经中药治疗后血清VEGF与治疗前相比较差异无统计学意义。结论VEGF的变化与银屑病之间具有疾病特异性，而证候及发展阶段的特异性不明显。抑制血管新生可能是凉血解毒方、养血解毒方治疗血热型和血燥型银屑病的机制之一。

英文摘要：

Objective To investigate the mechanism of Li Xue Jie Du Fang in the treatment of psoriasis vulgaris. Methods Totally 105 cases with psoriasis vulgaris classified as blood heat syndrome, blood-dryness syndrome, and blood stasis syndrome according to the traditional Chinese medicine （TCM） differentiation-types were studied. Serum levels of vascular endothelial growth factor（VEGF） in patients and normal controls were measured by enzyme-linked immunosorbent assay before and 8 weeks after treatment. Results Compared with the data of normal controls, the serum levels of VEGF in the patients were significantly increased （P 〈 0.01 ） , while a significant difference of the serum levels of VEGF in patients with blood heat syndrome and blood-dryness syndrome was observed between the before and after treatment values（P 〈 0.05）. Conclusion These results indicated that Li Xue Jie Du Fang could reduce the serum levels of VEGF in patients with psoriasis vulgaris. This study suggested that suppression of angiogenesis may be one of the mechanisms of Li Xue Jie Du Fang in the treatment of psoriasis vulgaris.