中文摘要：

造血干细胞是具有自我更新能力并能分化为血液中各种血细胞组分的多能干细胞。近来研究显示，不同造血千细胞表面标志物标记的造血干细胞具有分化为不同血细胞的趋势，但是这种分化的内在关系仍不清楚。对小鼠CD34-／Sca-1＋骨髓造血干细胞、外周血组成随小鼠年龄增长的变化情况进行了分析，结果显示：随着年龄的增长，骨髓中的CD34-／Sca—1＋骨髓造血干细胞比率显著增加：而外周血各组分则随年龄变化呈现不同的趋势。对不同年龄段小鼠的骨髓造血干细胞及其他组分与外周血组分的同步分析发现，外周血中血小板密度变化趋势与CD34-／Sca-1^＋骨髓造血干细胞变化情况相关系数为0．8048；外周血中淋巴细胞密度变化趋势与CD34^＋／Sca-1^-骨髓细胞的变化情况相关系数为0．94797；外周血中白细胞密度变化趋势与CD34＋／Sca-1^＋骨髓细胞变化情况相关系数为0．7631f大于0．9为极度相关，0．7到0．9为高度相关）。

英文摘要：

Peripheral blood cells are known to be derived from a self renewing population of hematopoietic stem cells residing in the bone marrow, but the relation between hematopoietic stem cells and the cells of peripheral blood is rarely understood. We explore the changes of CD34-/Sca-1＋ hematopoietic stern cell population in bone marrow and peripheral blood composition of C57BL/6J mouse during aging. The CD34-/Sca-1 ＋ cell population in bone marrow is increasing during the aging. We also study on the tendency of different cell lineages in peripheral blood and compare the tendency with that of bone marrow cells. The tendency of blood platelet density in peripheral blood shows high correlation with the percentage current of CD34-/Sca-1＋ bone marrow hematopoietic stem cells. The tendency of lymphocyte density in peripheral blood shows extreme correlation with the percentage current of CD34＋/Sca-1- bone marrow cells. The tendency of white blood cell density in peripheral blood shows high correlation with the percentage current of CD34＋/Sca-1＋ bone marrow cells.