中文摘要：

目的：探讨慢性阻塞性肺疾病肺血管重塑的研究进展。方法：总结、归纳、分析近年来的相关文献资料。结果：目前研究显示慢性阻塞性肺疾病（COPD）肺血管重塑、肺动脉高压是发展至肺心病的关键环节,内皮素-1（ET-1）、转化生长因子-β（TGF-β）、血管内皮细胞生长因子（VEGF）、人结缔组织生长因子（bFGF）、碱性成纤维细胞（CTGF）等多种细胞因子参与并影响血管重塑的发生。结论：认识COPD血管重塑相关细胞因子的表达变化,对COPD病情发展机制的探讨和临床治疗产生深远的影响。

英文摘要：

Objective：To investigate the research progress of pulmonary vascular remodeling for chronic obstructive pulmonary disease（COPD）.Methods：The relevant literature in recent years was summed up,summarized and analyzed.Results：At present,studies have shown that pulmonary vascular remodeling of COPD and pulmonary hypertension is the key link to the development of pulmonary heart disease.ET-1,TGF-β,VEGF,bFGF,CTGF and other cytokines were involved and affected the vascular remodeling.Conclusion：Understanding changes of related cytokine expression of vascular remodeling for COPD can bring about a far-reaching impact for the mechanism of disease development and the clinical treatment of COPD.