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中文摘要：
生殖器疱疹（GH）已经跃升为全球第三大性传播疾病,艾滋病患者（本文为HIV-1阳性患者）合并GH感染率高达50％～90％.常规的阿昔洛韦类治疗GH在普通人群中的耐药率低于1％,在HIV-1（＋）患者中明显升高达4.2％ ～7.1％.通过分析两个HIV患者中耐药GH的临床病例,给HIV合并耐药GH的诊疗提供参考,揭示HIV患者中发生耐药GH面临的挑战.
英文摘要：
Genital herpes simplex （GH） has been up to the 3rd lead of sexual transmitted disease worldwide. 50% -90% HIV - 1 infected patients were co - infected with GH. Acyclovir therapy resistance among GH immunocompetent patients has remained lower than 1%, but the resistance rate among HIV patients were much higher： 4.2% -7.1%. The paper reviewed two cases of Acyclovir resistant HIV - 1 positive patients infected by GH to describe the atypical features and to reveal the challenges we are facing in the treatment for HIV/HSV co - infected patient.
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