中文摘要：

心房颤动是最常见的心律失常之一，是全球性的重大公共卫生负担。明确心房颤动的发生、发展机制，有利于指导临床进行综合防治。心房颤动心房电重构是心房颤动时心房肌细胞电生理特性的改变，然而其机制尚未明确。炎症与心房颤动密切相关，高敏C反应蛋白、白细胞介素6、肿瘤坏死因子α、巨噬细胞移动抑制园子等炎性因子以及他汀类、肾素-血管紧张素．醛固酮系统抑制剂、糖皮质激素等抗炎药物均参与心房电重构的过程。

英文摘要：

Atrial fibrillation （AF）, the most prevalent sustained arrhythmia,is a major public health burden worldwide. To guide the clinical comprehensive prevention and treatment, it is particularly important to clarify the underlying mechanisms of AF. Electrical remodeling in AF refers to the changes of atrial myocytes in electrophysiological properties as a result of AF, but its specific mechanisms are still poorly understood. The inflammation and AF is closely related and the role of inflammatory factors including C reactive protein,interleukin 6, tumor necrosis factor α, macrophage migration inhibitory factor as well as statins, renim-angiotensiraldosterone system inhibitors, corticosteroids and other anti-inflammatory drugs are involved in the process of atrial electrical remodeling.