中文摘要：

非人类的首领(NHP ) 提供有力的试验性的模型学习人的开发，认知功能和骚乱以及复杂行为，因为他们到人的基因、生理的类似。因此， NHP 是为人的疾病的学习的适当模型，例如包括 Parkinson 的， Alzheimer 的并且亨廷顿的疾病的 neurodegenerative 疾病，它由于基因变化发生。然而，折磨人的如此的疾病不在 NHP 自然地发生。那么转基因的 NHP 需要被证实理解疾病病理和致病的病原学。把基因模型，比作啮齿类动物为人的疾病的转基因的 NHP 的产生是低效的，并且为亨廷顿的疾病的一个仅仅转基因的猴子模型被报导了。这评论为产生转基因的 NHP 学习人的疾病集中于潜在的途径和作出贡献的因素。

英文摘要：

Nonhuman primates （NHPs） provide powerful experimental models to study human development, cognitive functions and disturbances as well as complex behavior, because of their genetic and physiological similarities to humans. Therefore, NHPs are appropriate models for the study of human diseases, such as neurodegenerative diseases including Parkinson＇s, Alzheimer＇s and Huntington＇s diseases, which occur as a result of genetic mutations. However, such diseases afflicting humans do not occur naturally in NHPs. So transgenic NHPs need to be established to understand the etiology of disease pathology and pathogenesis. Compared to rodent genetic models, the generation of transgenic NHPs for human diseases is inefficient, and only a transgenic monkey model for Huntington＇s disease has been reported. This review focuses on potential approaches and contributing factors for generating transgenic NHPs to study human diseases.