中文摘要：

目的研究气溶胶颗粒在人体上呼吸道模型内的沉积规律，探索有毒气溶胶在人体上呼吸道的致病机理。方法采用ABS材料制作人体上呼吸道实验模型，搭建人体上呼吸道内气溶胶颗粒沉积的实验台，开展不同呼吸流量（30、60IVmin）条件下不同粒径（0．3、6．5μm）的气溶胶颗粒在人体上呼吸道模型中的沉积实验。结果不同呼吸流量下不同粒径气溶胶颗粒在人体上呼吸道模型内沉积模式趋势一致，在咽部、喉部和气管部位沉积较多，且喉部沉积最多。结论呼吸流量对模型内气溶胶颗粒沉积率影响较大，大粒径气溶胶更易沉积到模型中，惯性碰撞和湍流强度是气溶胶颗粒沉积的主要机制。

英文摘要：

Objective To examine the aerosol particle deposition in human upper respiratory tract model and ex- plore the pathogenesis of toxic aerosol in human upper respiratory tract. Methods A human upper respiratory tract model was constructed using ABS （ Acrylonitrile Butadiene Styrene） plastic, and an experimental system was established to measure the deposition efficiency of aerosol particles with different diameters （0.3 or 6.5 μm） at different breathing intensity （30 or 60 L/min） in this model. Results The deposition patterns of aerosol parti- cles with different diameters and at different breathing intensity in human upper respiratory tract model were simi- lar. The deposition efficiency was generally higher in pharynx, larynx and trachea while being the highest in the ar- ea of larynx. Conclusions The breathing intensity has a major impact on aerosOl deposition efficiency in the model. Larger aerosol particles are more easily to deposit in the model. Inertial impaction and turbulence intensity are the main mechanisms of aerosol particle deposition.