中文摘要：

目的：探讨麝香、冰片对脑缺血-再灌注损伤大鼠急性期及恢复早期的保护作用及机制。方法：将180只大鼠随机分为假手术组,模型组,麝香高、低剂量组（50、25 mg/kg）,冰片高、低剂量组（50、25 mg/kg）,醒脑静10m L/kg组。各组大鼠灌胃给药4 d,线栓法复制脑缺血-再灌注模型,观察麝香、冰片对脑缺血-再灌注炎性损伤急性期及恢复早期神经功能缺损评分、脑组织匀浆环氧酶（COX-2）和5脂氧酶（5-LOX）活性变化及海马组织Cys LT2蛋白及mRNA表达的影响。结果：麝香、冰片能显著提高脑缺血-再灌注损伤大鼠神经功能缺损评分,改善其脑组织病理形态,降低脑内COX-2和5-LOX的活性,抑制脑海马组织Cys LT2蛋白表达。结论：麝香、冰片能对抗大鼠脑缺血-再灌注急性期炎性损伤,其机制可能与抑制脑内COX-2与5-LOX的活性有关。

英文摘要：

Objective： To investigate the mechanism of Musk and Borneol on cerebral ischemia and reperfusion injury at different time points of acute phase in rats. Methods： 180 rats were divided into seven groups including sham,ischemia-reperfusion after 24 h and72 h model group,Musk 50 and 25 mg / kg groups,Borneol 50 and 25 mg / kg groups,and Xingnaojing 10 m L / kg group. Ischemia-reperfusion model was made after administration of each drug. The neurologic impairment scores at different time points after ischemia and reperfusion was evaluated,activities of cyclooxygenase（ COX-2） and 5-lipoxygenase（ 5-LOX） in brain tissue were determined,and the expression of Cys LT2 protein and mRNA in hippocampus were explored. Results： Musk and Borneol significantly improved the neurologic impairment scores of ischemia-reperfusion injury rats,improved the pathological morphology of rats brain tissue,reduced the activities of COX-2 and 5-LOX in brain homogenates,and inhibited the expression of Cys LT2 protein in hippocampus. Conclusion： Musk and Borneol have protective effect on inflammatory injury of acute injury in ischemia-reperfusion injury rats,the mechanism is related to inhibition the activity of COX-2 and 5-LOX in brain.