中文摘要：

目的：探究脂肪酸结合蛋白4（ FABP4）对人主动脉内皮细胞分泌基质金属蛋白酶2（ MMP2）的影响。方法：体外培养的人主动脉内皮细胞分别用转化生长因子-β（ TGF-β）及TGF-β加FABP4抑制剂HTS01037处理，检测处理前后内皮标志物CD31、VE-钙黏蛋白（ VE-Cad ）的mRNA表达，以及FABP4、MMP2的mRNA表达。结果：人主动脉内皮细胞用TGF-β处理后，内皮标志物CD31与VE-Cadherin mRNA表达升高，FABP4与MMP2的mRNA表达也升高（均P＜0.05）；用TGF-β加 HTS01037处理后，与单用TGF-β处理相比， CD31、VE-Cad及FABP4、MMP2的表达均降低（均P＜0.05）。结论：FABP4与TGF-β促进内皮细胞分泌MMP2的病理过程正相关。

英文摘要：

Objective：To investigate the roles of fatty acid binding protein 4 （ FABP4 ） in the process of human aortic endothelial cells secreting matrix metalloproteinase-2 （ MMP2 ） .Methods： Human aortic endothelial cells were treated with TGF-βalone and TGF-β＋FABP4 inhibitor HTS01037 respectively, and the mRNA level of CD31, VE-Cadherin, FABP4 and MMP2 were detected before and after the treatments.Results：When treated with TGF-βalone,human aortic endothelial cells express higher level of CD31 and VE-cadherin, as well as FABP4 and MMP2（all P 〈0.05）.When treated with TGF-βtogether with FABP4 inhibitor HTS01037, the human aortic endothelial cells express lower CD31,VE-Cadherin,FABP4 and MMP2（all P〈0.05）.Conclusion：FABP4 has a positive correlation with the process of endothelial cells secreting MMP2 promoted by TGF-β.