中文摘要：

正规 Wnt/-catenin 小径在开发，动态平衡，以及 tumorigenesis 起一个中央作用。小径的规定包含各种各样、复杂的机制，包括细胞外，细胞内部并且 endonuclear 规定。作为小径的关键部件， Lef1/Tcfs -- catenin 建筑群也是在原子核的规定的关键目标。在当前的评论，我们将在能修改 Wnt/-catenin 小径的 transcriptional 活动的原子核总结管理者。

英文摘要：

Canonical Wnt/β-catenin pathway plays a central role in development, homeostasis, as well as tumorigenesis. The regulation of the pathway involves various and complicated mechanisms, including the extracellular, intracellular and endonuclear regulation. As the key component of the pathway, the Lefl/Tcfs-β-catenin complex is also the key target of regulation in the nucleus. In the current review, we are going to summarize the regulators in the nucleus which can modify the transcrip- tional activity of the Wnt/β-catenin pathway.