中文摘要：

鞘氨醇-1-磷酸（S1P）是鞘磷脂代谢产生的一种生物活性脂类,参与细胞的多种基本功能,如细胞增殖、迁移、存活及细胞间信号转导等。S1P信号通路可以调节免疫细胞迁移、调节血管再生、参与肿瘤发展等。S1P在细胞内由鞘氨醇经特定的鞘氨醇激酶（SPHK）催化生成,也可经S1P磷酸化酶或S1P裂解酶（S1PL）分解,从而保证了人体生理环境中S1P的动态平衡。S1P可作为第二信使直接作用于细胞内靶标,也可以被转运蛋白转运到细胞外与相应受体（S1PR）结合后发挥生物效应。以S1P信号通路为靶点的药物研发是目前医药领域研究的热点。本文简要介绍了S1P信号通路的生理功能及相关的药物研究进展。

英文摘要：

Sphingosine-1-phosphate（S1P）, a bioactive sphingolipid produced by the metabolism of sphingomyelin, regulates cell proliferation, migration, survival and cell-cell contacts. The sphingosine-1- phosphate signaling pathway can regulate the trafficking of lymphocyte, angiogenesis, the progress of cancer and many other cellular functions. The formation of S1P is catalyzed by sphingosine kinases（SPHK）, and degraded by lyases（S1PL）, therefore S1P level is subject to a dynamic balance in the physiological environment. S1P can act as a second messenger or couple with S1P receptors（S1PR） to exert effects. The targets in the S1P signaling pathway have received considerable attention. Here we review the physiological function and drug development of S1P signaling pathway.