中文摘要：

目的观察姜黄素衍生物（Curc-OEG）抗肝纤维化作用及其机制。方法将雄性SD大鼠共分成4组：正常组、模型组、姜黄素衍生物组和姜黄素组。用四氯化碳诱导大鼠形成肝纤维化模型,2个治疗组分别尾静脉注射100 mg·kg^-1Curc-OEG和灌胃400 mg·kg^-1姜黄素。10周后,测肝功及肝纤维化指标、肝组织羟脯氨酸（Hpy）水平;HE、天狼星红染色,免疫组化法观察TGF-β1及α-SMA表达;RT-PCR法测TGF-β1 mRNA水平;Western blot测TGF-β1及α-SMA蛋白表达。结果与模型组比较,Curc-OEG能改善肝功及降低肝纤维化指标,降低Hpy含量及肝纤维化程度,抑制TGF-β1及α-SMA的表达。结论 Curc-OEG具有明显的抗肝纤维化作用。

英文摘要：

Objective To investigate the effects and its mechanisms of curcumin derivatives（Curc-OEG） on experimental rat hepatic fibrosis.MethodsMale SD rats were divided into four groups ：normal group,model group,curcumin derivatives group and curcumin group.Rat model of hepatic fibrosis was induced by CCl4,and then the model rats given with intravenous injection of 100 mg·kg^-1 Curc-OEG and 400 mg·kg^-1 curcumin.After treatment for 10 weeks,liver function,serum markers of hepatic fibrosis,liver Hpy content level were detected.The HE and Sirius red staining of hepatic fibrosis were observed and the progression of hepatic fibrosis was to grade,immunohistochemical for TGF-β1 and α-SMA in rat liver tissue were distributed.The liver tissue of TGF-β1 and Collagen I mRNA levels were detected by RT-PCR.The protein expression of TGF-β1 and α-SMA were detected by Western blot.ResultsCompared with model group,Curc-OEG could improve liver function and reduce serum levels of liver fibrosis,decrease levels of liver Hpy content,inhibitting the expression of cytokine TGF-β1 and α-SMA in liver tissue.ConclusionThe Curc-OEG has a significant effect of anti-liver fibrosis.