中文摘要：

痤疮是发生于毛囊皮脂腺的一种慢性炎症性疾病，发病机制尚不完全清楚。目前认为，主要与雄激素、皮脂分泌增多、毛囊导管的异常角化、痤疮丙酸杆菌感染、外界因素、机体的免疫反应和遗传有关。近年来研究表明，痤疮是一种多基因遗传病，尤其是重型痤疮与遗传密切相关。CYP11α、CYP17、CYP1A1、雄激素受体基因、CYP21等基因被认为是痤疮易感基因。因此，探讨痤疮的易感基因，对痤疮尤其是重型痤疮的早期诊断、治疗和预防具有重要意义。

英文摘要：

Ache is a common chronic inflammatory disease affecting hair follicles and sebaceous glands with unclear pathogenesis. It is a multifactorial disease and several pathogenetic factors have been identified, including the increase of androgen and sebum excretion, follicular hyperkeratinization, infection with Propionibacterium acnes, external factors, innate immunity, genetics, etc. Latest studies have indicated that ache is a polygenic disease and there is a particularly close correlation between severe acne and heredity. Many predisposing genes have been discovered for acne, including human CYP11α gene, CYP17 gene, CYP1Algene, androgen receptor gene, CYP21 gene, etc. Therefore, the investigation into susceptible genes for ache may be beneficial to the early diagnosis, treatment and prevention of severe acne.