中文摘要：

目的：腹腔脂肪型丝氨酸蛋白酶抑制剂（vaspin）是新发现的脂肪因子,对代谢性疾病具有预防作用。该研究旨在探讨血浆vaspin浓度与冠心病及不稳定型心绞痛的关系。方法：经血管造影诊断明确的冠心病患者88例（其中稳定型心绞痛47例,不稳定型心绞痛41例）,同期入院的103例无心脏疾病的患者作为对照。测量患者血浆中vaspin的浓度,记录临床一般情况及血脂、血糖、高敏C反应蛋白等指标。并根据冠状动脉的病变支数来评定冠心病严重程度。结果：不稳定型心绞痛的血浆vaspin浓度（0.43±0.38）μg/L较稳定型心绞痛（0.91±0.95）μg/L显著降低（P〈0.01）。在冠心病患者中血管病变支数与血浆vaspin浓度负相关（r=-0.350,P〈0.01）。ROC曲线分析血浆vaspin对冠心病有鉴别价值（AUC=0.684,P〈0.001）,对不稳定型心绞痛也有鉴别价值（AUC=0.640,P=0.024）。结论：不稳定型心绞痛患者具有较低的血浆vaspin浓度;低血浆vaspin浓度与冠心病严重程度呈相关。

英文摘要：

Objective：Vaspin was recently identified adipokine,playing a protective role in metabolic disease.The present study aimed to investigate the relationship of vaspin plasma level with stable angina pectoris（SAP） and unstable angina pectoris（UAP）.Method：A total of 88 patients with angiographically-provedCAD（SAP 47,UAP 41） and 103 control subjects without cardiovascular diseases were enrolled in this study.Circulating vaspin,clinical parameters,lipid profile,and high-sensitivity CRP were assayed.The severity of CAD was also assessed according to the number of vessel diseased.Result：There are significant difference（P0.01） in circulating vaspin level between SAP（[0.91±0.95]ng/mL） and UAP（[0.43±0.38]ng/mL）.An inverse association between the number of diseased vessels and plasma vaspin was observed（r=-0.350,P0.01） in the CAD group.Construction of receiver operating characteristic curves confirmed that vaspin plasma concentration significantly differentiated CAD patients（AUC=0.684,P0.001）,as well as UAP（AUC=0.640,P=0.024）.Conclusion：Vaspin plasma levels were decreased in patients with UAP;Low vaspin concentrations correlate with CAD severity.Our findings suggested that vaspin could serve as a novel biomarker of CAD.