中文摘要：

组蛋白去乙酰化酶6（HDAC6）是位于胞浆中的一种去乙酰化酶，参与调控细胞内多种重要的生物活性，可使α-微管蛋白（α-tubulin）、热休克蛋白90（Hsp90）和皮肌动蛋白（cortactin）去乙酰化，并与多种蛋白质缔结形成复合物。在细胞培养中，当产生的错误折叠蛋白超过了分子伴侣再折叠及泛素蛋白酶体系统（UPS）处理能力时，HDAC6可将其特异转运到细胞核周结构——异常蛋白包涵体（aggresome）中，从而使之被自噬有效降解，因此认为HDAC6在异常蛋白降解中发挥了关键的调控功能，是“蛋白构象病”的潜在治疗靶点。

英文摘要：

Histone deacetylase 6 （HDAC6） is a cytoplasmic enzyme that regulates many important biological processes. It deacetylates α-tubulin, Hsp90 and cortactin, and forms complexes with other partner proteins. When the misfolded proteins are too more to be degradated by the chaperone refolding system and the ubiquitin-proteasome system in cultured cells, misfolded proteins are specifically transported to a cytoplasmic juxtanuclear structure called aggresome by HDAC6, facilitating their clearance by autophagy. The diverse functions of HDAC6 in misfolded proteins degradation pathway suggest that it is a potential therapeutic target for the treatment of ＂conformational diseases＂.