中文摘要：

越来越多的研究证据已经表明,血清中低水平的维生素D3（VD3）与较高的结直肠癌（CRC）风险相关。目前大多数的观察性研究支持血清中25-（OH）-VD3水平与CRC风险呈负相关性。然而,口服VD3或饮食中补充VD3可否改善CRC患者的总生存期,目前还存在争议。本文将对近年来VD3与CRC相关性的研究作一综述,以期有更多前瞻性的基础研究、临床研究和人群观察性研究对VD3是否对CRC的预防和治疗有价值做出澄清。

英文摘要：

It is increasingly recognized that low levels of serum vitamin D3（VD3） are associated with a greater risk of colorectal cancer（CRC）. The majority of observational studies supported that serum 25-（OH）-VD3 concentration has inverse relationships with the risk of CRC. However, whether oral vitamin D3 intake or supplemental vitamin D3 in diet could improve CRC patients’ survival remains controversial. This review will summarize the recent findings about the relationship between VD3 and CRC, and more and more prospectively basic research, clinical trials and population studies will be needed to clarify that whether VD3 owns a value in CRC prevention and treatment.