中文摘要：

目的：探讨难治性肺炎支原体肺炎（ RMPP ）患儿免疫功能变化及匹多莫德的干预作用。方法：50例RMPP 患儿及50例健康儿童纳入本研究，将RMPP 患儿随机分为A、B两组，A组患儿予常规阿奇霉素联合匹多莫德治疗，B组患儿常规阿奇霉素治疗，检测对照组儿童及RMPP 患儿治疗前后外周血T细胞亚群的变化，并比较A、B两组患儿的临床疗效。结果：RMPP 患儿与对照组比较，血清CD3＋、CD4＋、CD4＋／CD8＋明显降低，差异有统计学意义（ P＜0．05）；治疗后，A、B两组RMPP 患儿血清CD3＋、CD4＋及CD4＋／CD8＋比值较治疗前明显升高，且A组明显高于B组水平，差异均有统计学意义（ P＜0．05）；随访期间A组患儿平均病情反复次数、持续时间及使用抗生素时间均明显少于B组，差异均有统计学意义（ P＜0．05）。结论：难治性肺炎支原体肺炎患儿存在免疫功能紊乱，匹多莫德可通过调节免疫平衡，增强患儿免疫力，进而提高临床疗效。

英文摘要：

Objective：To investigate the change of immune function and effect of immune intervention in children with refractory mycoplasma pneumoniae pneumonia （ RMPP ） .Method：50 children with RMPP and 50 cases of healthy children were studied ,and RMPP children were randomly divided into groups A , B, group A were treated with conventional azithromycin , group B were combined with pidotimod , the peripheral blood T cell subsets were etected in control and RMPP children （before and after treatment）,and clinical ef-ficacy were compared. Result： The level of serum CD3＋ ,CD4＋ and CD4＋/CD8＋ in RMPP children was sig- nificantly lower than the control group（ P〈0.05 ） ; after treatment, the level of serum CD3＋ , CD4＋ and CD4＋/ CD8＋ in group A and B was significantly higher than before treatment, and those in group A was significantly higher than group B, the differences were statistically significant （P〈0.05） ; the average number of iterations illness, duration and time of use of antibiotics in group A were significantly less than group B （P〈0.05）. Conclusion： There＇s immune dysfunction in children with RMPP, pidotimod can regulate the immune bal- ance, strengthen the immune system in children, and to improve clinical efficacy.