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Clustering of Inflammatory Biomarkers and Risk of Hypertension in a Mongolian Population in China
  • ISSN号:0895-3988
  • 期刊名称:BIOMEDICAL AND ENVIRONMENTAL SCIENCES
  • 时间:2012.10
  • 页码:562-568
  • 分类:Q51[生物学—生物化学] P618.130.1[天文地球—矿床学;天文地球—地质学]
  • 作者机构:[1]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China, [2]Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China, [3]Department of Health Care, Xiamen Maternal and ChiM Care Hospital, Xiamen 361000, Fujian, China
  • 相关基金:This study was supported by the National Natural Science Foundation of China (Grant No. 30972531) and a Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions.
  • 相关项目:抗磷脂抗体作为缺血性脑卒中预后生物标志的研究
中文摘要:

在那里的目的几乎不是上的很少知识煽动性的 biomarkers 正在聚类例如 C 反应的蛋白质(CRP ) ,可溶的细胞内部的粘附 molecule1-1 (sICAM-1 ) ,和血管收缩素 II (Ang II ) ,在有在蒙古的人口的高血压的个人。在现在的学习,我们在中国在一张蒙古的人口调查了这种关系。2589 成年 Mongolians 全部的方法 A, 20 岁以上,作为学习参加者被招募。人口分布,生活方式,高血压的家庭历史,血压,和血化学上的数据被收集,并且煽动性的 biomarkers 在所有参加者被测量。结果有二或三 biomarkers 的增加的层次的题目的比例在有高血压的那些是显著地更高的(21.0% 和 6.0% ,分别地) 比在那些与 prehypertension (12.7% 和 0.5% ,分别地) 或 normotension (8.1% 和 0.2% ,分别地) 。高血压的调整机会比率(95% 信心间隔) 与一,二或三 biomarkers 的增加的层次联系了的 multivariate 是 0.94 (0.721.22 ) , 1.42 (0.932.16 ) ,并且 11.08 (1.4584.80 ) ,分别地与没有任何 biomarker 的增加的题目相比。结论高血压在蒙古的人口与煽动性的 biomarkers 的簇被联系。

英文摘要:

Abstract Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (slCAM-1), and angiotensin It (Ang Ⅱ), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants. Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker. Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.

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期刊信息
  • 《生物医学与环境科学:英文版》
  • 主管单位:卫生部
  • 主办单位:中国疾病预防控制中心
  • 主编:陈春明
  • 地址:北京昌平区昌百路155号中国CDC
  • 邮编:102206
  • 邮箱:bes@chinacdc.cn
  • 电话:010-58900401 58900445传
  • 国际标准刊号:ISSN:0895-3988
  • 国内统一刊号:ISSN:11-2816/Q
  • 邮发代号:
  • 获奖情况:
  • 首届国家优秀期刊三等奖,第三届中国出版政府奖提名奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),英国农业与生物科学研究中心文摘,荷兰文摘与引文数据库,美国生物医学检索系统,美国科学引文索引(扩展库),美国生物科学数据库,日本日本科学技术振兴机构数据库
  • 被引量:330