在那里的目的几乎不是上的很少知识煽动性的 biomarkers 正在聚类例如 C 反应的蛋白质(CRP ) ,可溶的细胞内部的粘附 molecule1-1 (sICAM-1 ) ,和血管收缩素 II (Ang II ) ,在有在蒙古的人口的高血压的个人。在现在的学习,我们在中国在一张蒙古的人口调查了这种关系。2589 成年 Mongolians 全部的方法 A, 20 岁以上,作为学习参加者被招募。人口分布,生活方式,高血压的家庭历史,血压,和血化学上的数据被收集,并且煽动性的 biomarkers 在所有参加者被测量。结果有二或三 biomarkers 的增加的层次的题目的比例在有高血压的那些是显著地更高的(21.0% 和 6.0% ,分别地) 比在那些与 prehypertension (12.7% 和 0.5% ,分别地) 或 normotension (8.1% 和 0.2% ,分别地) 。高血压的调整机会比率(95% 信心间隔) 与一,二或三 biomarkers 的增加的层次联系了的 multivariate 是 0.94 (0.721.22 ) , 1.42 (0.932.16 ) ,并且 11.08 (1.4584.80 ) ,分别地与没有任何 biomarker 的增加的题目相比。结论高血压在蒙古的人口与煽动性的 biomarkers 的簇被联系。
Abstract Objective There is little knowledge on whether there is clustering of inflammatory biomarkers, such as C-reactive protein (CRP), soluble intracellular adhesion molecule1-1 (slCAM-1), and angiotensin It (Ang Ⅱ), in individuals with hypertension in the Mongolian population. In the present study, we investigated this relationship in a Mongolian population in China. Methods A total of 2589 adult Mongolians, aged 20 years and older, were recruited as study participants. Data on demographics, lifestyle, family history of hypertension, blood pressure, and blood chemistry were collected, and inflammatory biomarkers were measured in all participants. Results The proportion of subjects with increased levels of two or three biomarkers was significantly higher in those with hypertension (21.0% and 6.0%, respectively) than in those with prehypertension (12.7% and 0.5%, respectively) or normotension (8.1% and 0.2%, respectively). The multivariate adjusted odds ratios (95% confidence interval) of hypertension associated with increased levels of one, two or three biomarkers were 0.94 (0.72-1.22), 1.42 (0.93-2.16), and 11.08 (1.45-84.80), respectively, compared with subjects with no increase in any biomarker. Conclusion Hypertension was associated with a cluster of inflammatory biomarkers in the Mongolian population.