中文摘要：

目的研究抗菌肽LL-37刺激银屑病患者外周血T细胞分泌白介素-8（IL-8）的作用。方法用酶联免疫吸附试验（ELISA）的方法检测LL-37刺激前后健康人和银屑病患者外周血中IL-8的表达变化。结果在健康人外周血中，未受LL-37刺激的T细胞不能产生IL-8；在LL-37刺激后，可见IL-8的表达升高，且有时间和剂量依赖性，12h产生IL-8的量最多。在银屑病患者外周血中，未受LL-37刺激的T细胞可产生少量IL-8；LL-37刺激后，可见IL-8的表达升高，8h时IL-8的产生量已经相当于正常细胞12h的产生量，12h产生量更多。结论LL-37刺激银屑病患者外周血T细胞，其产生IL-8的速度比健康人T细胞更快，剂量更大。

英文摘要：

Objective To investigate the role of antimicrobial peptide LL-37 on IL-8 secretion from T cells in psoriatic peripheral blood. Methods The levels of IL-8 protein in peripheral blood of the healthy people and psoriasis were detected by ELISA. Results It could not produce IL-8 from T cells in peripheral blood of healthy peo- ple without stimulation of LL-57 ; while stimulated by LL-37, IL-8 was overexpressed. And LL-37 stimulated T ceils resulted in a dose and time-dependent production and reached a maximum after 12 hours. In psoriatic patients it could produce a little IL-8 from T cells stimulated by LL-37. And stimulated by LL-37, IL-8 was also overexpressed. IL-8 reached the same value of 8 hours after 12 hours in normal people and reached a maximum after 12 hours. Conclusion It is faster and more in psoriatic patients than that in healthy people for LL-37 to stimulate peripheral blood to produce IL-8.