中文摘要：

DNA甲基化与脑胶质瘤的发生发展关系密切。胶质瘤中的许多基因如DNA修复基因、细胞周期调控基因、细胞凋亡相关基因、肿瘤抑制基因、侵袭相关基因等的启动子区胞嘧啶一磷酸一鸟嘌呤位点富集区（CpG岛）存在高甲基化。胶质瘤多个基因的甲基化谱和特异分子标志物的发现有助于胶质瘤的病理分级、早期诊断、判断预后。同时，DNA甲基化具有可逆转的特性，这可能为胶质瘤的治疗提供新的途径。

英文摘要：

DNA methylation is closely related to the genesis and development of glioma. The CpG islands hypermethylation in promoter region of DNA repair genes, cell cycle controlling genes, apoptosis related genes, tumor suppressor genes and invasion related genes are found in glioma. Finding the specific methylation profile and molecular marker of glioma is helpful for the pathology class, early diagnosis and prognostic evalua- tion. Meanwhile, DNA methylation has the characteristic of reversibility, which may provide new ways for the treatment of glioma.