目的观察橡木皂苷对四氯化碳致大鼠肝纤维化的保护作用。方法采用质量分数为40%的四氯化碳皮下注射诱导大鼠肝纤维化模型,MASSON染色观察肝组织病理学改变,采集血清检测肝功能及透明质酸(hyaluronicacid,HA)、层黏连蛋白(1aminin,LN)、三型胶原蛋白(typesⅢ-col—lagen,COI-Ⅲ)含量的变化。结果梅木皂苷可抑制肝假小叶的形成和胶原纤维沉积,改善肝功能,降低血清中HA、LN、COI—III的含量(P〈0.05)。结论惚木皂苷有显著的抗肝纤维化的作用。
Objective To study the protection effects of Aralia saponins on carbon tetrachloride (CCI4 )in- duced liver fibrosis in rats. Methods The rat model of liver fibrosis was induced by hypodermic injection of 40% CC14. Hepatic histopathology was observed by MASSON staining. Serum levels of hepatic function and HA ( hyaluronic acid, HA ), LN ( laminin, LN), COI-m ( types III-collagen, COI-III ) were detected. Results Aralia saponins could suppress the formation of pseudolobule and deposition of collagen fibers in hepatic fi- brosis rats, and improve hepatic function, and reduce HA, LN, COI- m in serum ( P 〈 0. 05 ). Conclusion Aralia saponins have an anti-hepatic fibrosis effect.