欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
目的：探讨地塞米松对兔海水淹溺性肺水肿（PE-SWD）模型的治疗作用及其对血清IL-8、TNF-α及IL-10的影响。方法：40只家兔随机分为对照组（CG,10只）和不同剂量（0.05 mg/kg、0.2 mg/kg、1.0 mg/kg）地塞米松治疗组（DG1、DG2、DG3,各10只）。用酶联免疫法（ELISA）测定淹溺前及淹溺后30、120 min血清中IL-8、TNF-α及IL-10的含量,并进行动脉血气分析。结果：与CG组比较,DG2、DG3组PaO2升高（P〈0.05）,IL-8、TNF-α含量显著下降（P〈0.01）,IL-10含量明显增加（P〈0.01）;DG2组与DG3组比较,PaO2、IL-8、TNF-α、IL-10无明显变化（P〉0.05）。结论：较大剂量地塞米松能减轻肺损伤,其机制可能与抑制IL-8、TNF-α的释放,增加IL-10的生成有关。但增加剂量（1 mg/kg）并不能增加治疗效果。
英文摘要：
Objective：To investigate the therapeutical effect of dexamethasone on rabbits with pulmonary edema induced by seawater drowning and detect the changes of serum IL-8,TNF-α and IL-10 levels.Methods： Forty rabbits were randomly divided into 4 groups： control group（CG）,dexamethasone group（0.05 mg/kg as DG1,0.2 mg/kg as DG2,1 mg/kg as DG3）.The levels of serum IL-8,TNF-α,and IL-10 were examined by ELISA.Arterial blood gas was analyzed.Results：Compared with CG,the PaO2 in DG2 and DG3 was increased（P0.05）,the serum IL-8 and TNF-α levels were decreased（P0.01）,the serum IL-10 levels was increased（P0.01）.There was no significant difference between DG2 and DG3（P0.05）.Conclusion：Dexamethasone at comparatively high dose attenuates lung injury after seawater drowning,which may be related to the IL-8,TNF-α reduction and IL-10 increase.However,higher dose（1 mg/kg） can not improve the treatment effect.
同期刊论文项目
同项目期刊论文
期刊信息
位置：