中文摘要：

目的探讨老年女性阴道镜活检准确性及相关影响因素。方法回顾性分析近4年来，因宫颈病变行阴道镜下活检和宫颈锥切术的老年患者（大于等于50岁）110例，采用自身对照法，对比研究宫颈锥切术和阴道镜下活检的病理检查结果，并结合患者绝经情况、宫颈鳞柱交界及HPV情况进行分析。结果老年妇女宫颈锥切术与阴道镜下活检的病理检查结果符合者46例（41．8％），不符合者64例（58．2％）。在不符合者中，阴道镜活检病理低于锥切病理的37例（33．6％），高于锥切病理的27例（24．6％）。其中，绝经后妇女阴道镜下活检的准确率下降，宫颈鳞柱交界未见者阴道镜下活检的准确率降低，HPV检测值高者阴道镜下活检的准确率较低。结论老年女性阴道镜下活检的准确性下降，与绝经、HPV值及宫颈鳞柱交界未见因素相关。

英文摘要：

Objective To invest the accuracy of the colposcope directed cervical biopsies for elderly women. Methods A retrospective analysis was performed on 110 elderly women （over 50 years old） who underwent cervical intraepithelial neoplasia （CIN） in the hospital between Jan. 2009 and Feb. 2012. The study focused on the comparative analysis from pathological results between colposcope directed cervical biopsies and cervical conizationes. Results Of the 110 patients, 46 （41.8%） patients＇ pathology results of colp0scope directed cervical biopsies matched the cervical conizationes. Among those 64 patients whose results didn＇t match, there were 37 （33.6%） with more severe pathological results, 27 （24.6%） with mild results. The accuracy dropped for those women with menopause in the colposcope directed cervical biopsies and those with high value of Human papilloma virus （HPV） test. Conclusion The accuracy of the colposcope directed cervical biopsies declined for elder women, especially for those women with menopause. It is also related with high value of HPV test and unsatisfied squamocolumnar junction （SCJ）.