中文摘要：

主要组织相容性复合体（major histocompatibility complex,MHC）I类分子四聚体（tetramer）技术可直接对抗原特异性细胞毒性T淋巴细胞（cytotoxic T lymphocytes,CTL）进行标记,以检测能够识别特定抗原肽-MHC I的CTL,用于临床检测、疾病诊断及相关科学研究。综述了MHC I四聚体技术应用的最新研究进展,为开展四聚体的相关研究提供新的参考。

英文摘要：

The tetramer technology in major histocompatibility complex class I （MHC I） can be used to label the antigen-specific cytotoxic T lymphocytes （CTLs） directly so as to detect the CTLs, which can recognize the specific antigenic peptide-MHC I. The MHC I tetramer technology can be applied in clinical test, disease diagnosis and scientific research. In this article, the novel progress on the application of the MHC I tetramer technology is reviewed fully to provide a new reference to research in tetramer.